This website uses cookies to ensure you get the best experience. Learn more

Senior Research Scientist I, Drug Metabolism, PK Modeler

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.

Job Description

Gilead Sciences, Inc. is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/ AIDS, liver diseases, serious respiratory and cardiovascular conditions, cancer and inflammation, headquartered in Foster City, California.  As a Research Scientist / Senior Research Scientist, you will join the Drug Metabolism & Pharmacokinetics (DMPK) group in research, working closely with biology, protein biochemistry, toxicology, clinical pharmacology, pharmaceutical sciences, and regulatory to optimize leads, to select biologic candidates for clinical evaluation, and contribute to IND/ IMPD and NDA/ BLA filings.

Gilead’s core values of integrity, inclusion, teamwork, excellence, and accountability shape our culture and are the foundation of our future success.  Challenge yourself and make a difference in the world – Being Here Matters.

The primary responsibilities of a PK modeler would be to provide PK, PK/PD analysis and ADME assessment to support discovery and development teams.

Job Responsibilities:

  • Serve as subject matter and task -oriented DMPK expert on dynamic cross-functional teams, conducting PK/PD, PBPK modeling in translation of in vitro ADME and transport information to predict in vivo PK and human efficacious dose, providing data interpretation, and presentations to discovery and development teams.
  • Work closely with project teams, line management and CROs to assure high quality and timely delivery of written reports for regulatory submissions. Propose testing strategies to project teams and characterize ADME/transport kinetics and implement mathematical tools for human PK prediction and assessment of drug-drug interactions (DDI) of investigational new molecular entities.
  • Prepare study protocols and coordinate execution of pre-clinical PK studies, which may involve multiple functional areas and CROs.
  • Supervising or performance management of associate scientists may be required.

Knowledge, Experience and Skills:

  • 3+ years of experience with Ph.D. in pharmaceutical sciences, cell/molecular biology or related field with some industrial experience in drug transport/metabolism.
  • Previous experience with PK/PD, PBPK model analysis for human PK prediction is preferred. Experience in transporter/enzyme kinetics assessment and the application of PK modeling software systems (e.g. MatLab/ SimBIO SimCYP, Phoenix/ WinNonlin, or similar) is necessary.
  • The candidate will possess strong work ethics, problem solving skills, and ability to work independently in a focused, goal-oriented manner. The ability to interact and collaborate with scientists from various disciplines and functional areas is vital to this role.
  • The candidate will be able to seek evidence of productivity and independence through authorship of research in peer-reviewed publications.
  • Excellent interpersonal, written and oral communication skills are prerequisites to perform in a highly-matrixed team environment.


For jobs in the United States:

As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact for assistance.

For more information about equal employment opportunity protections, please view the ‘EEO is the Law’ poster.



Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.

Apply Now

Share this