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Senior Research Scientist II, PK Modeler, Drug Metabolism

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.

Job Description

Gilead Sciences, Inc. is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, serious respiratory and cardiovascular conditions, cancer and inflammation, headquartered in Foster City, California.

Specific Responsibilities:

An experienced mathematical modeler, with a focus upon pharmacokinetics and drug metabolism, ideally with a track record in broad application in Drug Discovery and Drug Development.  Responsibilities will be divided between being a modeling resource supporting the drug metabolism department (and other groups within Research) and also a department representative on specific Drug Research and Development teams which would benefit for modeling support.  The focus is upon providing a mechanistic understanding of drug absorption and disposition, and application of the understanding in various pharmacodynamic models.  Experience in prediction of human pharmacokinetics is essential.  Experience with working with both small molecules and biologics is an asset.

Essential Duties and Job Responsibilities:

  • Develop and apply mathematical models for diverse needs at all stages in Drug Discovery and early Drug Development.
  • Serve as a subject matter expert in prediction of human pharmacokinetics from physicochemical, in vitro and nonclinical data.
  • Design and perform complex PK analysis, model development and PK/PD analyses to answer translational questions and to provide DMPK guidance for project teams.
  • Serve as DMPK subject matter expert on dynamic cross-functional teams, to define ADME strategy to achieve target product profile, provide in vitro and in vivo drug disposition and DDI data, interpretation and presentations to teams.
  • Makes major contributions to scientific literature and conferences through publication and presentation of research results.
  • Ability to communicate and educate others on complex areas of DMPK science as a technical expert.  Could be a deep expert in one area with working knowledge of other aspects of drug disposition.

Knowledge, Experience and Skills:

  • Requires a highly motivated individual with PhD degree in life sciences with 7+ years of experience
  • BS or MS degree with extensive industry experience.
  • Demonstrates excellent scientific verbal, technical communication and interpersonal skills. Must be organized, pay attention to details and have strong organizational and planning skills.
  • Prior experience contributing to the discovery and development of a drug candidate from preclinical through clinical trials is an asset
  • A critical understanding of commercial PBPK software (e.g. Simcyp or GastroPlus) plus experience in application of general purpose modeling software (e.g. Berkeley Madonna, SAAM II, SimBiology, PML, NONMEM) and familiarity with data handling (e.g. R, MATLAB)
  • Demonstration of development of custom PK, PBPK, PKPD and/or PopPK models



For jobs in the United States:

As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact for assistance.

For more information about equal employment opportunity protections, please view the ‘EEO is the Law’ poster.



Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.

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