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Scientific Leader

The newly formed Functional Genomics group at GSK comprises of several disciplines that provide the deep scientific knowledge and technical capabilities required to discover and validate potential novel therapeutic targets through the application of extensive genetic analyses, high throughput genome editing and endophenotyping in well-characterized human cellular models.

An exciting opportunity is available for a highly motivated and experienced scientist to fill a Scientific Leader position within Functional Genomics, Stevenage. The successful candidate will be responsible for the conceptual design and execution, both directly and by leadership, of large scale functional genomics studies in disease-relevant systems for target discovery, validation and pathway studies of critical importance to the GSK R&D pipeline. Potential areas of investigation are broad and encompass Oncology, Immunology and genetically driven disease mechanisms. However, the scientist will have a particular responsibility for Oncology and will contribute to setting and delivery of Oncology strategy with Functional Genomics both at the level of cancer biology and by evaluation and implementation of the most appropriate state of the art genomic methodologies, both in-house and through outsourcing, and will ensure timely analysis and interpretation of large data sets.

Key Responsibilities:
- Design and implementation of functional genomics studies with a particular focus on oncology research priorities, employing physiological- and/or disease-relevant cellular models and assays
- Active role in driving oncology strategy within Functional Genomics at GSK
- Working in a matrix team environment to drive timely delivery of project and department objectives to the highest scientific standard
- Evaluate and implement innovative technologies as appropriate to ensure GSK is highly competitive in functional genomics and facilitate their broad implementation across ongoing target discovery and validation efforts
- Ensure compliance with all GSK R&D data integrity practices, ethics codes, standards and training, and safety training and practices.

Closing date for applications: 28th Match 2019

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.

If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

When applying for this role, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

Thank you for your interest in this opportunity.


Why You?Basic qualifications:
- Ph.D. or equivalent in Genomics/Biological Sciences with extensive oncology research experience in industry or academia in the area of target identification and validation.
- Extensive practical experience in the experimental design, execution and data analysis of experiments to identify new oncology targets using genomics and other approaches.
- Evidence of conducting and interpreting perturbation studies using tool compounds, gene knockdown or gene editing approaches in cancer cell lines eg. CRISPR, siRNA.
- Evidence of conducting and applying NGS approaches (DNAseq,RNASeq, CHIPseq) in the study of primary tumour cells or cell lines.
- Demonstrated ability to analyse complex integrated datasets across multiple genomics platforms.
- Demonstrated ability to conduct and interpret cancer cell line cell viability and colony forming assays in the presence of compounds with appropriate use of statistical tests and models in exploring the relationship between genomic mutation and compound response.
- Demonstrated ability to review and critically appraise oncology target validation campaigns.
- Strong publication record in oncology functional genomics.
- Evidence of managing complex projects across lines and functions.
- Excellent team-working behaviours, matrix working, interpersonal and communication skills.
- Evidence of working in large academic collaborations with the ability to build relationships.
- Strong influencing and analytical skills coupled with the ability to problem solve.
- Highly committed, enthusiastic, self motivated and demonstrate a passion for learning.

Preferred qualifications:
- Ability to formulate and communicate a coherent vision/research plan
- Good understanding of genetics
- Evidence of leading new technology initiatives, working with commercial partners to evaluate and implement new technologies relevant to target validation.
- Evidence of setting up and managing external CRO arrangements for executing target validation experiments.
- Evidence of successful leadership of matrix teams.
- Knowledge of pharmacological principles and the ability to interpret the effects of drugs in complex cellular assay systems.

Why GSK?:
At GSK, our mission is to improve the quality of human life by enabling people to do more, feel better and live longer. Our three world-leading businesses research and deliver innovative medicines, vaccines and consumer healthcare products. We need a talented and motivated workforce to deliver against our strategy. To achieve this, we strive to attract the best people and to create an environment that empowers and inspires.

Contact information:
You may apply for this position online by selecting the Apply now button.

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